Multifunctional biocompatible films based on <scp>pectin?Ag</scp> nanocomposites and <scp>PVA</scp> : Design, characterization and antimicrobial potential

Pectin-Ag nanocomposites with a core-shell structure are synthesized by the “green chemistry” method based on reduction of silver nitrate pectin (amidated, low-, or high methoxylated) in an alkaline medium at room temperature. TEM and DLS measurements show that average size inorganic core (10–30 nm) hydrodynamic diameter nanocomposite (284.8–649.2 depend type pectin. The films pectin-Ag polyvinyl alcohol (PVA) different molecular weight (30, 66, 145 kDa) obtained casting evaporation technique. A comparative study their mechanical, optical, degradation antibacterial properties is carried out. smaller Ag exhibit higher antimicrobial activity against Bacillus strains. pectin-Ag/PVA loaded antibiotic kanamycin (KAN). Prolonged release pronounced (up to full inhibition) effect pectin-Ag/PVA/KAN Escherichia coli, Pseudomonas aeruginosa, pumilus, subtilis due formation pectin-Ag/KAN complexes. Moreover, potency resistant strains aeruginosa. multifunctional expected find promising applications biomedical engineering wound healing.